Application of BES |CAS：10191-18-1|in cosmetics

More and more cosmetic formulations use active ingredients obtained through microbial fermentation engineering. In the aspect of resisting skin aging, yeast fermentation product extract has a good promoting effect on skin cell regeneration and collagen synthesis; The main ingredients of microbial fermentation product extract for skin care are peptides and nucleic acids. Peptides and nucleic acids have good resistance and protection against the damage caused by heat, free radicals, heavy metals and toxins to skin cells. However, when polypeptides and nucleic acids are added to cosmetics as effective ingredients, they are easily inactivated, because such bioactive ingredients usually require pH to be stable at 6.0-8.0. Therefore, the existing skin care products need a buffer ingredient that is safe, non-toxic and with good physiological compatibility. This ingredient can maintain the pH value of the product at 6.0-8.0 within the three-year shelf life of the cosmetics, to solve the technical problem that the product pH drift causes the microbial fermentation product extract added to the skin care products to lose efficacy.
The CN102793657B patent provides a skin care product containing biological buffer that can make the pH value stable at 6.0-8.0 within three years after preparation. The technical solution adopted is to add a biological buffer with a mass percentage of 0.1% - 3.0% to the skin care product containing the extract of microbial fermentation products. The biological buffer is selected from one of PIPES, ACES, MOPSO, Bis-Tris Propane,N, N-bis (2-hydroxyethyl) - 2-aminoethanesulfonic acid, MOPS, N-(diethylsulfamoyl)-N-ethylethanamine, HEPES, CHPS-NA, TAPSO、HEPPSO  or their mixture.
The above N, N-bis (2-hydroxyethyl) - 2-aminoethanesulfonic acid is abbreviated as BES , and CAS is 10191-18-1. It is an organic compound with molecular formula of C6H15NO5S and molecular weight of 213.25. BES is a biological buffer, widely used in laboratory research and development and chemical and pharmaceutical synthesis. YACOO can provide customers with high-quality services of BES from gram to ton.

Reference
CN102793657B A skin care product containing biological buffer.