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NT-proBNP and troponin T, effective way to detect coronary heart disease

2017-10-16 来源:亚科官网
16 October 2017
  Recently, researchers from Uppsala University have developed a new tool that uses NT-proBNP and troponin T in blood to coronary heart disease and stable coronary heart disease, which makes it possible to give patients with coronary artery disease a more precise and tailor-made treatment. The tool makes it possible to identify those who have the highest risk, in order to achieve preventive treatment.
  Heart disease is a more common type of circulatory system diseases, the survey shows that there is one person died of heart disease every 3 minutes in China. In all heart disease, coronary heart disease is the most common type. The main cause of coronary heart disease is arterial stenosis caused by coronary atherosclerosis, which can cause heart ischemia, angina pectoris, palpitation, shortness of breath, body fatigue and a series of symptoms, even life-threatening. Stable coronary heart disease is a class of coronary heart disease that the degree of angina pectoris, frequency, and predisposing factors have no significant changes in a few weeks.
  Because stable coronary heart disease has no significant fluctuations, the patient may be not clear on their own condition, or do not pay attention to the treatmenteasy, resulting in adverse consequences. Therefore, for coronary heart disease, predictive diagnosis and treatment are equally important. In order to better predict the diagnosis of coronary heart disease, scientists have made unremitting efforts to seek new test method in addition to arterial angiography, and found that the blood test is also a big tool: In 2015, ASGES (for age/gender/gene expression) blood tests can help doctors quickly and safely assess whether the patient's chest discomfort is due to obstructive coronary heart disease; in 2016, Mayo Clinic found that by testing the concentration of plasma ceramide, it can be determined whether those patients with signs of coronary artery disease is obvious at risk of heart attack; In 2017, the British Heart Foundation noted that troponin testing can predict the risk of heart attack.
  In this study, the researchers showed that two blood detection methods included more information than any other factors: one of which was NT-proBNP, In the state of stress and in the presence of coronary heart disease, the heart will secrete this precursor; the other one is highly sensitive cardiac troponin T, which is a key protein found in the cardiomyocytes, myocardial Loss of troponin will leak into the blood when the myocardium is damaged, it can be used to assist in the diagnosis of the disease.
  In the current treatment, antithrombotic treatment of coronary heart disease is very important, the main drugs are aspirin (acetyl salicylic acid), chloropyrrole (2-thienethylethylamine as substrate) and Ticlopidine (2-Thiophene ethanol as substrate), the role is to inhibit platelet aggregation, prevent thrombosis and block blood vessels, but the risk of bleeding during treatment also increased. Through the combination of special blood tests and some clinical factors, the new technologies may also help to develop a new therapy which is more safe to treat coronary heart disease.
Related links: 2-thienylethylamine
Edited By Suzhou Yacoo Science Co., Ltd.