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Research team from China and US develops smart diabetes treatment patch

2019-04-03 来源:亚科官网
 
Since the 21st century, diabetes has remained one of the biggest obstacles to human health worldwide. Loss of control of blood glucose regulation is often accompanied by a variety of complications, such as eye, kidney and nerve lesions, which cause great pain to the patient. Although there are already relatively effective drugs for diabetes on the market, multiple daily injections are often not conducive to patient compliance, restricting the final treatment effect, and greatly improving the treatment cycle and cost.
Glucose-responsive drug delivery potential is huge
In recent years, in order to reduce the frequency of injection, a variety of long-acting drug sustained-release preparations based on synthetic materials have been or are under investigation. Among them, the blood glucose responsive drug delivery system shows great potential. Elevated blood glucose levels are often accompanied by changes in the physiological environment, and specific glucose oxidation reactions can provide a localized hypoxic, low pH, and hydrogen peroxide-rich environment. Based on this, the environmentally responsive material can spontaneously regulate the release rate of the drug according to the blood glucose concentration, rapidly release the drug at the high blood sugar level, slow down or even suspend the drug release at the normal blood sugar level, and exhibit an intelligent drug controlled release behavior. However, it should be pointed out that the current glycemic response type delivery system often constructs the glucose response module and the drug release module in the same material, and the release of the drug is accompanied by the loss of the glucose response material, so that multiple and efficient blood glucose cannot be guaranteed. response. A more responsive and smarter drug controlled release system is being developed.
New blood glucose responsive microneedle patch
In order to solve the above problems, the research team of the National Institutes of Health and Sun Yat-sen University developed a new type of blood glucose responsive microneedle patch. In the patch, the researchers constructed a glucose response module and a drug release module by means of biomimetic mineralization. The anti-diabetic drug Exendin-4 is loaded in a calcium phosphate-based composite particle to spontaneously degrade and release the drug at a lower pH. Glucose oxidase is supported in a composite particle based on copper phosphate, which can regulate the rate of glucose oxidation reaction according to blood glucose concentration, thereby regulating the pH of the local environment. The two modules are simultaneously loaded into a sodium alginate-based microneedle patch at a certain ratio. The smart patch can be conveniently applied to the human body through the skin, and at the same time, the release rate of the drug is spontaneously regulated according to the blood glucose concentration, and the blood sugar level is intelligently regulated. Among them, the use of degradable calcium phosphate minerals and non-degradable copper phosphate mineral materials respectively achieves the rapid release of the drug and the stability of the glucose response module, ensuring long-term regulation of blood glucose levels.
As described above, the constructed smart patch can greatly enhance the convenience of administration while increasing the action time of the drug. The patient can be relieved from the heavy burden of administration and enjoy a better life under the premise of effectively controlling his own symptoms.
Edited by Suzhou Yacoo Science Co., Ltd.