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India invents hydrogels that develop epidermal cell components faster and better

2019-04-12 来源:亚科官网
 
Researchers at the Indian Institute of Technology, Mumbai, used a non-cytotoxic hydrogel made of polyacrylamide instead of a traditional plastic tissue culture dish to grow more of the major constituent cells of the epidermis in the laboratory—keratin formation cell. Researchers report in the British Journal of Progress in the Royal Society of Chemistry that the new method uses the tension between cells and materials to allow functional keratinocytes to multiply rapidly, independent of feeder layers or any exogenous drugs.
Hydrogel is a three-dimensional network structure containing a large amount of water, which is ubiquitous in biological systems. For example, sea cucumbers and jellyfish contain a large amount of hydrogel materials, and mammalian tissues are also composed of hydrogels. Currently, hydrogel systems based on a variety of materials are not broken, such as polymers, cellulose, chitosan, and even DNA. Based on the unique properties of hydrogel, such as flexibility and biocompatibility, it has been widely studied and applied in many fields such as electrical devices, sensors and biomedicine.
Hydrogel materials play an important role in the biomedical field, but most hydrogel materials have poor mechanical properties (such as the tensile strength of hydrogel materials still does not reach the strength of biological tissue (10 MPa)), very large to a limited extent, their practical utility. By constructing highly ordered internal structures in the network structure of hydrogels or introducing chemical and physical cross-linking structures, opportunities are provided for obtaining high-strength hydrogels.
Researchers at the Indian Institute of Technology, Mumbai, used a non-cytotoxic hydrogel made of polyacrylamide instead of a traditional plastic tissue culture dish to grow more of the major constituent cells of the epidermis in the laboratory – keratin formation cell. The team found that relatively less rigid hydrogel matrices allowed keratinocytes to proliferate rapidly to the 25th generation, while cells on plastic plates stopped growing after 12-15 passages. In addition, the keratinocytes produced on the hydrogel have better healing ability.
Keratinocytes are the main component of the epidermis, accounting for more than 90% of epidermal cells. The rapid proliferation of keratinocytes is essential for the treatment of patients with chronic wounds and burns.
Edited by Suzhou Yacoo Science Co., Ltd.