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Research team of Southwest University discovered new materials for electrochemiluminescence induced by aggregation induction

2019-06-26 来源:亚科官网
 
In the field of luminescence, the research of organic materials has received increasing attention. Because of the wide variety of organic compounds, the adjustability is good, the color is rich, the color purity is high, and the molecular design is relatively flexible. There are many kinds of organic small molecule luminescent materials, many of which have conjugated heterocyclic rings and various chromophores, and the structure is easy to adjust. The conjugate length is changed by introducing an unsaturated group such as an olefin bond or a benzene ring and various chromophores, thereby changing the photoelectric properties of the compound.
Aggregation-induced luminescent organic light-emitting materials have the characteristics of the more concentrated the strong the luminescence, and are widely used in organic light-emitting diodes (OLEDs), proton solvents, and bioluminescent probe systems.
Electrochemiluminescence (ECL) refers to the use of an electrode to provide energy to electrochemically and chemically react a luminescent substance near the surface of an electrode to form an excited state with high energy, and then return to an energy state with a relatively low energy state by an excited state. The process of radiating energy form has become one of the frontier areas of modern analytical science.
Recently, the research group of Southwest University published a paper in Analytical Chemistry, reported that Tetraphenylethylene (TPE) crystallites have significantly enhanced aggregation-induced electrochemiluminescence properties in aqueous solution, and further constructed an ECL biosensor that specifically detects mucin 1 (MUC1).
In this work, the authors first prepared hexagonal prismatic tetraphenylethylene microcrystals (TPE MCs) by self-assembly method, and found that this aggregated TPE (TPE MCs) compared with the TPE molecules in the free state, The ECL response in aqueous solution is increased by nearly 30 times. The reason for this is that from the structural analysis, the four benzene rings in the TPE with the propeller configuration are free to rotate in the molecular free state, which may consume energy through the non-radiative relaxation path. In TPE MCs, the movement of the four benzene rings in the molecule is limited, so that the non-radiative relaxation channel can be suppressed and the excited state radiation can be illuminated. Therefore, the authors define this phenomenon of TPE MCs as an aggregation-induced electrochemilumination enhancement driven by intramolecular motion. Subsequently, they combined the novel ECL material TPE MCs with the target-activated two-leg DNA walker to construct an ECL biosensor with specific detection of mucin 1 (MUC1) with a detection limit as low as 0.29 fg/mL. In summary, the proposed new mechanism of RIM-ECL enhancement opens a new chapter for the research and application of electroluminescent luminescence in the state of aggregation.
Edited by Suzhou Yacoo Science Co., Ltd.