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What are the applications of ethylenediaminetetraacetic acid?

2019-04-12 来源:亚科官网
Ethylenediaminetetraacetic acid (abbreviated as EDTA) is an amino polyacid. Because it can form a chelate with most metal ions, it becomes a universal type of strong chelating agent. In the past, the research on EDTA conjugates and hydrazines has three main aspects: First, the most stable metal chelates of EDTA-transition elements and rare earth elements are attracted to the research. Another important aspect is a batch of chelates with moderate complex strength, such as an alkaline earth metal complex. Because the general reagent is difficult to achieve complexation with the metal on the alkali, the EDTA alkaline earth metal complex attracts people's attention; the third aspect is through EDTA itself and the eutectic metal salt sequence, focusing on EDTA acid to proton Affinity research.
1. Additives for vacuum blood collection tubes
An additive for vacuum blood collection tubes, dipotassium edetate (EDTA-2K) (or EDTA-3K), anticoagulant 2 mL of blood requires EDTA-2K) 4mg. Because the concentration is small, in order to not dilute the blood, 20 μL of an aqueous solution containing 200 g/L of ethylenediaminetetraacetate (EDTA-2K) is usually placed in each blood collection tube. Since the blood collection tube is valid for two years, When the use environment changes slightly, such as temperature changes, moisture can easily evaporate to the pipe wall (especially the water in the solvent of the plastic PET pipe can leak through the pipe wall and leak out), causing the EDTA-2K to crystallize and crystallize quickly. After the EDTA-2K blood collection tube is arbitrarily inverted upside down at least 8 times, the crystallized diammonium EDTA (EDTA-2K) is fully dissolved and mixed in the blood. Evenly, if the action is slightly larger, the red blood cells will be destroyed and hemolyzed, and the platelets will be aggregated and broken.
At present, some people have proposed the concept of "dry spray": EDTA-2K crystal pulverization (using a ball mill or micronized), and then dry-spraying into each test tube, dry powder state of EDTA-2K and blood can be dissolved quickly, but the content of EDTA-2K in each blood collection tube should be accurately quantified within 4±0.4mg. The current "dry spray" technology in the world is still only an idea, because the 4 mg dry powder metering nozzle has not yet been introduced, and the "dry spray" technology cannot solve the aqueous solution of diammonium ethylenediamine tetraacetate (EDTA-2K). The pH value is between 4 and 5, and the possible hemolysis, platelet aggregation, adhesion, and breakage problems, especially the speed of addition by the "dry spray" method seriously affects the production capacity of the blood collection tube.
2. Prepare a toilet deodorant.
In parts by mass, including the following substances: 5-10 parts of acid salt, proper amount of ammonia water, 50-70 parts of alcohol, 5-10 parts of urotropine, dipotassium ethanediaminetetraacetate, proper amount of isobutanolamine, water 60 to 80 servings. The deodorant can not only deodorize but also prevent scale, and the use method is simple, the dosage is small, the duration is long, and the toilet bowl has no corrosive effect. The production method is simple, the raw material cost is low, and it is non-toxic, harmless and non-polluting.
3. Used as a complexing agent in liquid phase analysis.
According to the invention, there is provided a tetrabutylammonium hydrogen sulfate buffer salt system for liquid chromatography detection, wherein the solvent is water, and the solute comprises tetrabutylammonium hydrogen sulfate and a buffer ion pair, and the buffer ion pair is composed of potassium dihydrogen phosphate and phosphoric acid. The solute further includes a complexing agent, and the complexing agent is preferably dipotassium ethylenediaminetetraacetate. The tetrabutylammonium hydrogen sulfate buffer salt system provided above is stable within 24 hours, and no turbidity occurs; taking the analysis of related substances of moxifloxacin hydrochloride as an example, the tetrabutylammonium hydrogen sulfate buffer salt system which is left at room temperature for 24 hours can be seen. The chromatographic behavior of moxifloxacin, N-methyl impurities, impurity A, impurity B, impurity C, impurity D, and impurity E on the reversed-phase column was basically the same as that of the newly configured tetrabutylammonium hydrogen sulfate buffer salt system.
4. Prepare a metal polish agent 
The polishing agent is dipotassium ethylenediaminetetraacetate, trisodium phosphate, dibutyl phthalate, sodium silicate, inorganic acid, dicarboxylic acid compound, tetrameric ricinoleate, biological buffer, stabilizer The water-soluble surfactant and water are raw materials, and the scientific content ratio is prepared, thereby preparing the polishing agent to effectively remove impurities on the metal surface, etc., which is convenient to operate, has good polishing effect, and greatly improves production efficiency. It also ensures the cleanliness and gloss of the metal surface and improves the quality of the metal.
Related links: EDTA
Edited by Suzhou Yacoo Science Co., Ltd.