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Synthesis route and application of 1,3-propane sultone

2019-04-25 来源:亚科官网
1,3-propane sultone is an excellent sulfonate propylation reagent. It has strong reactivity with thiols, amines, alcohols, phenols, etc. It can improve the surface properties of chemical substances and is widely used in pharmaceutical and chemical industries. Materials, dyes, and surfactants and lithium batteries.
Synthetic route of 1,3-propane sultone
1,3-propane sultone is prepared according to different starting materials, and there are three synthetic routes with practical value.
(1) Synthetic route using n-propyl chloride as a raw material
The synthesis reaction process is complicated, the raw materials are toxic and volatile, the reaction process is not easy to control, and the yield is low.
(2) Synthetic route using acrolein as raw material
The synthesis reaction raw material is easily oxidized, and the process requires hydrogenation reduction, the reaction conditions are harsh, and the cost is high, and the yield is about 79%.
(3) Synthetic lines using propylene alcohol as raw material
Using propylene alcohol as a starting material, it is added with NaHSO3 to form sodium 3-hydroxypropane sulfonate, which is acidified to obtain 3-hydroxypropanesulfonic acid, which is then distilled under reduced pressure and dehydrated in the molecule to obtain 1,3-propanesulfonic acid. The synthetic route is
The synthesis reaction condition is mild, the raw material is cheap and easy to obtain, no toxic and explosive danger, no pollution to the environment, simple process and easy operation, and the yield can reach 95%.
Use of 1,3-propane sultone
It can be used in the synthesis of tanning, ink and sensitizing materials, 1,3-propane sultone is a new functional fine chemical material. It reacts with many kinds of compounds under very mild conditions, provides sulfonic acid groups accurately, and gives these compounds new properties. It is an excellent general-purpose sulfonating agent and an important pharmaceutical intermediate. It also can be used in brighteners, dyes, dual-ion surfactants, sulfonation.
Related links: 1,3-propane sultone
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