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How does α-glucosidase achieve hypoglycemic, what are the advantages?

2019-04-28 来源:亚科官网
 
Postprandial blood sugar remains high, which seems to be a common problem in Chinese diabetic patients. Often fasting blood sugar has been well controlled, and eating blood sugar is high, it is really difficult to do. Alpha-glucosidase inhibitors are a good solution to this problem. Alpha-glucosidase inhibitors are a class of oral hypoglycemic agents that delay the absorption of intestinal carbohydrates to treat diabetes. It is a relatively mature drug for the treatment of diabetes and has been widely used in clinical practice.
Mechanism of α-glucosidase hypoglycemic
α-glucosidase plays an important role in the absorption of food, and food must be combined with this enzyme to be digested and absorbed. Alpha-glucosidase inhibitors slow down the absorption rate of glucose in the intestinal tract by inhibiting α-glucosidase on the intestinal mucosa and reduce postprandial hyperglycemia. Because it does not stimulate insulin, it does not cause hypoglycemia itself, so it helps to reduce blood sugar fluctuations and keep blood sugar throughout the day.
Advantages of α-glucosidase inhibitors
Alpha-glucosidase inhibitors not only reduce postprandial hyperglycemia, but also cause hypoglycemia. This unique "peak-to-valley" effect helps reduce the risk of cardiovascular disease in diabetic patients. Alpha-glucosidase inhibitors are effective in reducing postprandial hyperglycemia through their unique mechanisms, with the following benefits.
(1) Reducing blood sugar fluctuations: significantly fluctuating damage to large blood vessels Severe α-glucosidase inhibitors can not only reduce postprandial hyperglycemia, but also cause hypoglycemia and avoid blood sugar fluctuations. This unique “peak elimination” The role of "valley" helps to reduce the risk of cardiovascular disease in diabetic patients.
(2) Significantly reduce the risk of type 2 diabetes: in people with impaired glucose tolerance postprandial blood glucose elevation is the main indicator of impaired glucose tolerance. Postprandial hyperglycemia can aggravate insulin resistance and insulin secretion defects, when islet β cell function is only about 50% left, fasting blood sugar rises, and those with impaired glucose tolerance develop type 2 diabetes. Therefore, controlling postprandial hyperglycemia is an important means to prevent patients with impaired glucose tolerance from developing into type 2 diabetes.
(3) Significantly reduce the incidence of cardiovascular events in diabetic patients. A large number of epidemiological studies and clinical trials have confirmed that postprandial hyperglycemia is a high risk factor for cardiovascular complications and death. Therefore, controlling postprandial hyperglycemia can significantly reduce diabetes patients. Risk of cardiovascular complications and death. Studies have shown that α-glucosidase inhibitors significantly reduce the incidence of cardiovascular events by 35%, with the most significant reduction in myocardial infarction and other cardiovascular events.
(4) Improve insulin resistance. α-glucosidase inhibitors do not lower blood sugar by stimulating insulin secretion. It lowers postprandial blood glucose and lowers postprandial insulin levels, indicating that it increases insulin sensitivity.
Related links: α-glucosidase
Edited by Suzhou Yacoo Science Co., Ltd.