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Brief Introduction of The Wide Application of The Diagnostic Reagent 4-Aminobenzamidine dihydrochloride

2020-04-30 来源:亚科官网

4-Aminobenzamidine dihydrochloride, CAS number: 2498-50-2. Its applications are extremely wide, and the most common use is as a competitive inhibitor of serine proteases.

4-Aminobenzimididine dihydrochloride is a ligand of affinity adsorbent, which can be combined with dextran gel to make bio-separation materials.

4-Aminobenzidine dihydrochloride will combine with some specific enzymes, which can simulate the effects of biological inhibition and antibodies. It is an inhibitor of many enzymes such as trypsin and urokinase, in addition to serine proteases. Among the enzyme competitive inhibitors found, 4-aminobenzidine dihydrochloride is one of the smallest compounds.

4-Aminobenzimididine dihydrochloride can also be used as a probe for ligand and serine protease active sites in affinity chromatography. In addition, 4-aminobenzimididine dihydrochloride is an important pharmaceutical intermediate, mainly used Intermediate of Bigatran Ester.

Dabigatran etexilate is a new type of direct thrombin inhibitor developed by Boehringer Ingelheim, Germany. It is mainly used to prevent stroke and systemic embolism in patients with non-valvular atrial fibrillation. Dabigatran etexilate can provide an effective, predictable, and stable anticoagulant effect, with fewer drug interactions, no drug-food interactions, and no need for routine coagulation function monitoring or dose adjustment. 4-Aminobenzimididine dihydrochloride is an important raw material for dabigatran etexilate, and is of great significance for the preparation and development of dabigatran etexilate.

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