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Chinese scholars have found a new pathogenesis of diabetes

2017-06-19 来源:转载自第三方
19 June 2017

  Recently, team of Professor Wang Weiqing and director Wang Qidi, from School of Medicine, Shanghai Jiaotong University, Department of Endocrinologists, Ruijin Hospital, their study revealed a new mechanism of diabetes etiology, found a new target for new target drug for diabetes. The related research results have been published in the international journal "Nature Communications".
  In recent years, the global incidence of diabetes has grown rapidly, it has become the third major serious threat to human health after the tumor, cardiovascular disease. According to the World Health Organization, by 2025, the number of adult diabetes will increase to 300 million, the number of Chinese patients with diabetes will reach 40 million, the next 50 years, diabetes will still be a serious public health problem in China. The pathogenesis of diabetes is becoming more and more mature, and it is generally believed that there are several factors: genetic factors, obesity and diet lifestyle and insulin resistance. In all pathogenesis, the key is the reduction of functional islet β cell capacity, which is the absolute number of β cells and the regulation of β cell function mature and differentiation, but its molecular mechanism is not clear.
  1, 4, 8, and 11 days after the birth of mice, respectively, are four critical periods of β cell function mature. In this study, scientists conducted pancreatic histological staining at these four critical time points and found that mTORC1 appeared to be the peak of expression, and for the first time, they successfully constructed the mice that islet β-cell was selective knockout mTORC1 key constituent protein Raptor, These mice developed dominant diabetes at 4 weeks after birth and had severe insulin secretion defects. The study found that Raptor can control the expansion of β-cell capacity by direct regulation of β cell size and apoptosis. The lack of differentiation of β-cell maturation is a pathologic feature of some patients with type 2 diabetes mellitus. Therefore, this kind of patients are expected to restore the dedifferentiated naive β cells to mature β cells with normal glucose-stimulating function by regulating the activity of mTORC1.
  mTORC1 is a target for the use of nutrients and a variety of hypoglycemic agents (sulfonylureas, metformin, DPP4 inhibitors). This original study not only reveals a new pathogenesis of diabetes mellitus, but also finds new target for the treatment of diabetes, it is also provides a new possibility to use cell transplantation for the treatment of diabetes, the study has important scientific and social significance.

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